Jonas Anderud on Guided Bone Regeneration Using Ceramic Membranes

................................................................. 13 LIST OF PAPERS ........................................................... 15 INTRODUCTION .......................................................... 19 Clinical problem ...................................................................19 Bone ...................................................................................19 Current methods of bone augmentation ...................................21 Autogenic grafts ..............................................................21 Allogenic grafts ...............................................................21 Xenogenic grafts ..............................................................22 Alloplastic grafts ..............................................................22 Other methods of augmentation .........................................22 Guided bone regeneration ....................................................24 Experimental vertical guided bone regeneration .......................27 Ceramics and Bio-ceramics ....................................................31 HYPOTHESIS ............................................................... 34 AIMS ......................................................................... 35 MATERIALS AND METHODS ........................................... 36 Preoperative investigations ....................................................36 Paper I-III .............................................................................37 Surface topography .........................................................39 Animals and anaesthesia and surgery ................................39 Preparation of samples .....................................................40 Three-dimensional trabecular bone analysis study 1 .............41 Histological analyses study 2 and 3 ...................................42 Statistics .........................................................................42 Paper IV ..............................................................................43 Surgery ..........................................................................44 Measuring of gained bone volume and soft tissue topographic ....................................................................45 Sample preparation .........................................................46 RESULTS ..................................................................... 47 Surface measurements ...........................................................47 Three dimensional results from micro-CT investigation ................47 Histological results ...............................................................52 Paper IV ..............................................................................57 Clinical outcome ..............................................................57 Materials ........................................................................58 Radiologic evaluation .......................................................59 Histological outcomes .......................................................60 DISCUSSION ............................................................... 61 Surface roughness ................................................................61 Material porosity ..................................................................63 Permeability .........................................................................64 Zirconia ..............................................................................65 Individualized membranes in a clinical situation .......................66 CONCLUSIONS ........................................................... 72 POPULÄRVETENSKAPLIG SAMMANFATTNING .................. 73 ACKNOWLEDGEMENTS ............................................... 75 REFERENCES ............................................................... 77 PAPERS I – IV ............................................................... 89